Boronate Based Metal-Free Platform for Diphosphate-Specific Molecular Recognitions

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• 作者：Mai Sanjoh ; Daisuke Iizuka ; Akira Matsumoto ; Yuji Miyahara
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：588-591
• 全文大小：270K
• ISSN：1523-7052

文摘

A reversible boronate鈥揹iol interaction provides a versatile synthetic platform for molecular recognitions whose binding specificity can be molecularly tailored. We found that boronate derivatives with relatively strong acidity generally undergo a diphosphate-specific recognition among other phosphates under weakly acidic pH conditions, a feature relevant to DNA sequencing. ¹¹B and ³¹P NMR studies identified 鈥渢etrahedral boronate and divalent diphosphate鈥?as a pair responsible for forming a 1:1 stoichiometric complex, which manifests as a unique pH-dependent stability.