Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene)

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• 作者：Yasunobu Matsumoto ; Kazuhiro Hibino ; Masahiro Yonaga ; Hideaki Kakeya ; Yujiro Hayashi
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：18
• 期：14
• 页码：3382-3385
• 全文大小：320K
• 年卷期：0
• ISSN：1523-7052

文摘

The first total synthesis of RQN-18690A (18-deoxyherboxidiene) and the determination of its absolute stereochemical configuration are described. The synthesis features an organocatalytic aldol reaction for the first step, 1,4- and 1,2- dual reductions of α,β-unsaturated δ-lactone followed by a domino reaction in a one-pot operation, and diastereoselective epoxidation with kinetic resolution.