Isolation of Ciliatamide D from a Marine Sponge Stelletta sp. and a Reinvestigation of the Configuration of Ciliatamide A

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• 作者：Yasufumi Imae ; Kentaro Takada ; Shigeru Okada ; Yuji Ise ; Hiroshi Yoshimura ; Yasuhiro Morii ; Shigeki Matsunaga
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：April 26, 2013
• 年：2013
• 卷：76
• 期：4
• 页码：755-758
• 全文大小：189K
• 年卷期：v.76,no.4(April 26, 2013)
• ISSN：1520-6025

文摘

A new lipopeptide, ciliatamide D (1), was isolated from a marine sponge Stelletta sp., collected at Oshimashinsone, together with the known compound ciliatamide A (2). Ciliatamide D (1) is a congener of 2, in which N-Me-Phe is replaced by N-Me-Met(O). Marfey鈥檚 analysis of the acid hydrolysate of 1 demonstrated that the two constituent amino acids were both in the l-form. This result prompted us to carefully investigate the configuration of 2, resulting in the assignment of the l-form for both residues.