Toxicogenomic Response to Chlorination Includes Induction of Major Virulence Genes in Staphylococcus aureus

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• 作者：Matthew Wook Chang ; Freshteh Toghrol ; William E. Bentley
• 刊名：Environmental Science & Technology
• 出版年：2007
• 出版时间：November 1, 2007
• 年：2007
• 卷：41
• 期：21
• 页码：7570 - 7575
• 全文大小：138K
• 年卷期：v.41,no.21(November 1, 2007)
• ISSN：1520-5851

文摘

Despite the widespread use of chlorination for microbialcontrol in aqueous environments, cellular responsemechanisms of human pathogens, such as Staphylococcusaureus, against chlorination remain unknown. In thiswork, genome-wide transcriptional analysis was performedto elucidate cellular response of S. aureus to hypochlorousacid, an active antimicrobial product of chlorination inaqueous solution. Our results suggest that hypochlorousacid repressed transcription of genes involved in cell wallsynthesis, membrane transport, protein synthesis, andprimary metabolism, while amino acid synthesis genes wereinduced. Furthermore, hypochlorous acid inducedtranscription of genes encoding major virulence factors ofS. aureus, such as exotoxins, hemolysins, leukocidins,coagulases, and surface adhesion proteins, which all playessential roles in staphylococcal virulence. This workimplies that chlorination may stimulate production of virulencefactors, which provides new insight into host-pathogeninteractions and effects of chlorine application for microbialcontrol.