文摘
The first synthesis of 2-amino-5-fluorothiazole hydrochlorideis reported from 2-aminothiazole. The synthesis proceeds in35% overall yield, involves no chromatographic purification,and has been employed to prepare multikilogram quantities ofthe title compound. The key fluorine-introducing step comprisesthe reaction of dilithiated 2-tert-butoxycarbonylaminothiazolewith N-fluorobenzenesulfonimide.