A Peptoid-Based Combinatorial and Computational Approach to Developing Ligands for Uranyl Sequestration from Seawater

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• 作者：Bernard F. Parker ; Abigail S. Knight ; Sinisa Vukovic ; John Arnold ; Matthew B. Francis
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2016
• 出版时间：April 20, 2016
• 年：2016
• 卷：55
• 期：15
• 页码：4187-4194
• 全文大小：401K
• 年卷期：0
• ISSN：1520-5045

文摘

The selective binding of uranyl for extraction from seawater by using polymer sorbents holds promise as a sustainable source of uranium for nuclear energy. A combinatorially synthesized peptoid library (N-substituted glycine oligomers) was screened for uranyl binding with the goal of identifying high-affinity ligands for use in polymer sorbents. Qualitative screening techniques using a dye, arsenazo III, identified three uranyl-binding sequences, all of which contained only carboxylic acids as the active binding groups. Fluorescence spectroscopy was used to determine a dissociation constant for one of the identified peptoids by monitoring the decrease in peptoid fluorescence upon uranyl binding. Density functional theory calculations were used to model the solution-state binding of these sequences to understand favored binding modes and geometries.