Engineering Light-Gated Ion Channels
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- 作者：Matthew R. Banghart ; Matthew Volgraf ; Dirk Trauner
- 刊名：Biochemistry
- 出版年：2006
- 出版时间：December 26, 2006
- 年：2006
- 卷：45
- 期：51
- 页码：15129 - 15141
- 全文大小：258K
- 年卷期：v.45,no.51(December 26, 2006)
- ISSN：1520-4995
文摘
Ion channels are gated by a variety of stimuli, including ligands, voltage, membrane tension,temperature, and even light. Natural gates can be altered and augmented using synthetic chemistry andmolecular biology to develop channels with completely new functional properties. Light-sensitive channelsare particularly attractive because optical manipulation offers a high degree of spatial and temporal control.Over the last few decades, several channels have been successfully rendered responsive to light, includingthe nicotinic acetylcholine receptor, gramicidin A, a voltage-gated potassium channel, an ionotropicglutamate receptor, 
-hemolysin, and a mechanosensitive channel. Very recently, naturally occurring light-gated cation channels have been discovered. This review covers the molecular principles that guide theengineering of light-gated ion channels for applications in biology and medicine.
-hemolysin, and a mechanosensitive channel. Very recently, naturally occurring light-gated cation channels have been discovered. This review covers the molecular principles that guide theengineering of light-gated ion channels for applications in biology and medicine.