Synthesis of Key Fragments of Leiodelide A

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• 作者：Mathieu F. Chellat ; Nicolas Proust ; Matthew G. Lauer ; James P. Stambuli
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：June 17, 2011
• 年：2011
• 卷：13
• 期：12
• 页码：3246-3249
• 全文大小：763K
• 年卷期：v.13,no.12(June 17, 2011)
• ISSN：1523-7052

文摘

The synthesis of all key fragments of the marine macrolide leiodelide A is described. The polyoxygenated northern subunit is derived from d-xylose, while the southern subunit is rapidly assembled via an aldol reaction and Horner鈥揥adsworth鈥揈mmons olefination. This highly convergent approach will allow for rapid modification and assembly of several isomers of leiodelide A, which may be necessary considering the assignment of leiodelide B has been previously shown to be incorrect.