Switchable Reconfiguration of a Seven-Ring Interlocked DNA Catenane Nanostructure

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• 作者：Chun-Hua Lu ; Alessandro Cecconello ; Xiu-Juan Qi ; Na Wu ; Stefan-Sven Jester ; Michael Famulok ; Michael Matthies ; Thorsten-Lars Schmidt ; Itamar Willner
• 刊名：Nano Letters
• 出版年：2015
• 出版时间：October 14, 2015
• 年：2015
• 卷：15
• 期：10
• 页码：7133-7137
• 全文大小：526K
• ISSN：1530-6992

文摘

The synthesis, purification, and structure characterization of a seven-ring interlocked DNA catenane is described. The design of the seven-ring catenane allows the dynamic reconfiguration of any of the four rings (R₁, R₃, R₄, and R₆) on the catenane scaffold, or the simultaneous switching of any combination of two, three, or all four rings to yield 16 different isomeric states of the catenane. The dynamic reconfiguration across the states is achieved by implementing the strand-displacement process in the presence of appropriate fuel/antifuel strands and is probed by fluorescence spectroscopy. Each of the 16 isomers of the catenane can be transformed into any of the other isomers, thus allowing for 240 dynamic transitions within the system.