17尾-Hydroxy-17伪-methylandrostano[3,2-c]pyrazole, Stanozolol: The Crystal Structures of Polymorphs 1 and 2 and 10 Solvates

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• 作者：Jolanta Karpinska ; Andrea Erxleben ; Patrick McArdle
• 刊名：Crystal Growth & Design
• 出版年：2011
• 出版时间：July 6, 2011
• 年：2011
• 卷：11
• 期：7
• 页码：2829-2838
• 全文大小：1254K
• 年卷期：v.11,no.7(July 6, 2011)
• ISSN：1528-7505

文摘

17尾-Hydroxy-17伪-methylandrostano[3,2-c]pyrazole, also known as stanozolol, is a synthetic steroid derived from testosterone. Crystals grown by sublimation provide the first solvent free crystal structures of polymorphs 1 and 2, and these are reported together with the structures of 10 solvates. Both polymorphs contain voids. Polymorph 1 is more stable has a higher density and a smaller void than polymorph 2 but also has unused hydrogen bonding capacity. The solvates exhibit a range of different hydrogen bonding networks and have no voids. Some of the structures have both tautomers of stanozolol present in the asymmetric unit.