Effect of glycounits on the antimicrobial properties and toxicity behavior of polymers based on quaternized DMAEMA

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• 作者：Marta 脕lvarez-Paino ; Alexandra Mu帽oz-Bonilla ; F谩tima L贸pez-Fabal ; Jos茅 L. G贸mez-Garc茅s ; Johan P.A. Heuts ; Marta Fern谩ndez-Garc铆a
• 刊名：Biomacromolecules
• 出版年：2015
• 出版时间：January 12, 2015
• 年：2015
• 卷：16
• 期：1
• 页码：295-303
• 全文大小：367K
• ISSN：1526-4602

文摘

Polymers with quaternary ammonium groups such as quaternized poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMAQ) have been used as antimicrobial agents because of their demonstrated good antimicrobial activities against a huge number and types of microbes, although their cytotoxicity is also well-known. In this work block copolymers based on PDMAEMAQ were synthesized containing hydrophobic segments of poly(butyl methacrylate) to improve the antimicrobial activity and glycomonomer units with the aim of decreasing the cytotoxicity of the polymers. Hydrophobic butyl methacrylate (BMA) blocks were chain extended by statistical and block copolymers of DMAEMA and 2-{[(d-glucosamin-2-N-yl)carbonylethyl methacrylate (HEMAGl) glycomonomer of different compositions. In order to find the balance between antimicrobial activity and cytotoxicity, the selectivity index of each polymer was obtained from minimum inhibitory concentrations (MIC) and white and red blood cells toxicity measurements.