Measurement and Prediction of Transient Transport across Sclera for Drug Delivery to the Eye

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• 作者：Mark R. Prausnitz ; Auré ; lie Edwards ; Jeremy S. Noonan ; David E. Rudnick ; Henry F. Edelhauser ; and Dayle H. Geroski
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：1998
• 出版时间：August 1998
• 年：1998
• 卷：37
• 期：8
• 页码：2903 - 2907
• 全文大小：59K
• 年卷期：v.37,no.8(August 1998)
• ISSN：1520-5045

文摘

Drug delivery to the eye for treatment of a number of important diseases involves non-steady-state transport across the sclera. Although the literature contains steady-state measurementsof permeability, the transient transport properties of sclera have not been determinedexperimentally or described theoretically. In this study, carboxyfluorescein flux across humansclera is shown experimentally to approach a quasi-steady state with a lag time of 0.37 h.Because drug-sclera contact times in the body are often shorter than this, the use of steady-state permeability models will overpredict the amount of drug delivered to the eye. A theoreticalmodel is also developed to describe the observed transient flux by accounting for both diffusionand solute binding within the sclera.