Aptamer-Nanoparticle Assembly for Logic-Based Detection
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- 作者：Mohammed I. Shukoor ; Meghan O. Altman ; Da Han ; Abdullah Tahir Bayrac ; Ismail Ocsoy ; Zhi Zhu ; Weihong Tan
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2012
- 出版时间：June 27, 2012
- 年：2012
- 卷：4
- 期：6
- 页码：3007-3011
- 全文大小：275K
- 年卷期：v.4,no.6(June 27, 2012)
- ISSN：1944-8252
文摘
In this work, gold nanoparticles perform Boolean logic operations in response to two proangiogenic targets important in cancer diagnosis and treatment: PDGF and VEGF. In the absence of protein target, gold nanoparticles are initially dispersed as a red solution; the addition of target proteins causes nanoparticle aggregation, turning the solution blue, as well as the release of dye-labeled aptamer probes, which causes an increase in fluorescence. These outputs constitute an AND or OR gate for simultaneous protein detection. We believe this logic-gate-based detection system will become the basis for novel rapid, cheap, and reliable sensors for diagnostic applications.