Effects of Loops and Nucleotides in G-Quadruplexes on Their Interaction with an Azacalixarene, Methylazacalix[6]pyridine

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• 作者：Ai-Jiao Guan ; En-Xuan Zhang ; Jun-Feng Xiang ; Qian Li ; Qian-Fan Yang ; Lin Li ; Ya-Lin Tang ; Mei-Xiang Wang
• 刊名：Journal of Physical Chemistry B
• 出版年：2011
• 出版时间：November 3, 2011
• 年：2011
• 卷：115
• 期：43
• 页码：12584-12590
• 全文大小：956K
• 年卷期：v.115,no.43(November 3, 2011)
• ISSN：1520-5207

文摘

A novel trend in G-quadruplex ligand design is to build a binder that is able to not only discriminate G-quadruplex from duplex-DNA, but also among various G-quadruplex structures. Methylazacalix[6]pyridine (MACP6), a new type of azacalixarene with flexible conformation, exhibits induced circular dichroism signals when interacted with most of G-quadruplexes. The intensities of the induced signals are strongly dependent on the topology of G-quadruplexes. Further evidence has shown that these signals can be ascribed to the preferred binding of MACP6 to the loops of G-quadruplexes, which rely on the nature of nucleotides in the loops.