The B(C6F5)3-Catalyzed Tandem Meinwald Rearrangement–Reductive Amination
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- 作者：Martine R. Tiddens ; Robertus J. M. Klein Gebbink ; Matthias Otte
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：August 5, 2016
- 年：2016
- 卷：18
- 期：15
- 页码：3714-3717
- 全文大小：294K
- 年卷期：0
- ISSN：1523-7052
文摘
A system of three coupled catalytic cycles enabling the one-pot transformation of epoxides to amines via Meinwald rearrangement, imine condensation, and imine reduction is described. This assisted tandem catalysis is catalyzed by B(C<sub>6sub>F<sub>5sub>)<sub>3sub> resulting in the first tandem Meinwald rearrangement–reductive amination protocol. The reaction proceeds in nondried solvents and yields β-functionalized amines. In particular, β-diarylamines are obtained in high yields.