Codendrimer from Polyamidoamine (PAMAM) and Oligoethylene Dendron as a Thermosensitive Drug Carrier

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• 作者：Yifei Guo ; Yanna Zhao ; Jing Zhao ; Meihua Han ; Afang Zhang ; Xiangtao Wang
• 刊名：Bioconjugate Chemistry
• 出版年：2014
• 出版时间：January 15, 2014
• 年：2014
• 卷：25
• 期：1
• 页码：24-31
• 全文大小：362K
• ISSN：1520-4812

文摘

The efficient synthesis of codendrimer PAMAM-co-OEG (PAG) and its properties in aqueous solution, including particle size and thermosensitivity, are described. PAG is synthesized with well-defined structure through the 鈥渁ttach to鈥?route. In the aqueous solutions, PAG forms unimer and multimolecular aggregates with the respective particle sizes of approximately 8 and 200 nm, depending on the concentration. PAG shows thermosensitive behavior with sharp and fast transition, and the lower critical solution temperature is 38.2 掳C. The suitability of codendrimer PAG as the thermosensitive carrier is evaluated with methotrexate (MTX) as the model drug. MTX is encapsulated in PAG with the drug-loading capacity of 39%, among which 30% of MTX is encapsulated in PAMAM core. The release behavior of MTX mediated by temperature is investigated with focus on the effects around the LCST of PAG.