Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment

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• 作者：Guoqiang Liu ; Meirong Cai ; Feng Zhou ; Weimin Liu
• 刊名：Journal of Physical Chemistry B
• 出版年：2014
• 出版时间：May 8, 2014
• 年：2014
• 卷：118
• 期：18
• 页码：4920-4931
• 全文大小：760K
• 年卷期：v.118,no.18(May 8, 2014)
• ISSN：1520-5207

文摘

The fabrication of core/shell charged polymer brushes-grafted hollow silica nanoparticles (PSPMA-g-HSNPs) is reported. Because of the excellent hydration capability of the shells consisting of charged polymer brushes, the functional nanoparticles can achieve a good lubricating effect in aqueous media via hydration lubrication mechanism. The mesoporous hollow silica cores endow the nanoparticles with drug loading鈥搑elease capability. Aspirin, as a useful drug for treating arthritis, was employed to carry out in vitro drug loading and release studies. It is clear that brushes-modified hollow silica exhibited long-term drug release performance. The combination of lubrication and drug loading capabilities results in the great clinical potential of new multifunctional nanoparticles as injectable joint lubricant fluid in arthritis treatment.