Enzymatic Resolution of N-Substituted-β-prolines

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• 作者：Javier Mendiola*^† ; ; Susana Garca-Cerrada*^† ; ; scar de Frutos^† ; ; Mara Luz de la Puente^† ; ; Rui Lin Gu^‡ ; ; Vien V. Khau^&#
• 刊名：Organic Process Research & Development
• 出版年：2009
• 出版时间：March 20, 2009
• 年：2009
• 卷：13
• 期：2
• 页码：292-296
• 全文大小：127K
• 年卷期：v.13,no.2(March 20, 2009)
• ISSN：1520-586X

文摘

A general and straightforward strategy for enzymatic resolution of N-substituted-β-proline has been successfully designed and developed in our research laboratories. A first affinity screen is followed by ratio enzyme/substrate optimization to source our chemistry groups N-substituted-β-proline in kilogram scale in an efficient and cost-effective way.