Reaction of 2-Bromomethylazoles and TosMIC: A Domino Process to Azolopyrimidines. Synthesis of Core Tricycle of the Variolins Alkaloids

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• 作者：Javier Mendiola ; José ; M. Minguez ; Julio Alvarez-Builla ; and Juan J. Vaquero
• 刊名：Organic Letters
• 出版年：2000
• 出版时间：October 19, 2000
• 年：2000
• 卷：2
• 期：21
• 页码：3253 - 3256
• 全文大小：60K
• 年卷期：v.2,no.21(October 19, 2000)
• ISSN：1523-7052

文摘

A new reaction of N-protected 2-bromomethylazoles and tosylmethyl isocyanide (TosMIC) leading to the preparation of azolopyrimidines isdescribed. This domino sequence was used to synthesize the pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine core of alkaloids variolins from 4-methoxy-2-methylpyrrolo[2,3-b]pyrimidine in two steps.

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