Cytotoxic Norsesquiterpene Peroxides from the Endophytic Fungus Talaromyces flavus Isolated from the Mangrove Plant Sonneratia apetala

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• 作者：Hanxiang Li ; Hongbo Huang ; Changlun Shao ; Huarong Huang ; Jieyi Jiang ; Xun Zhu ; Yayue Liu ; Lan Liu ; Yongjun Lu ; Mengfeng Li ; Yongcheng Lin ; Zhigang She
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1230-1235
• 全文大小：811K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Four new norsesquiterpene peroxides, named talaperoxides A鈥揇 (1鈥?b>4), as well as one known analogue, steperoxide B (5, or merulin A), have been isolated from a mangrove endophytic fungus, Talaromyces flavus. Their structures were elucidated mainly by 1D and 2D NMR. Structures of 1, 2, and 5 were further confirmed by single-crystal X-ray diffraction, and their absolute configurations were also determined using copper radiation. Cytotoxic activities of compounds 1鈥?b>5 were evaluated in vitro against human cancer cell lines MCF-7, MDA-MB-435, HepG2, HeLa, and PC-3. Compounds 2 and 4 showed cytotoxicity against the five human cancer cell lines with IC₅₀ values between 0.70 and 2.78 渭g/mL.