Cytotoxic Cycloartane Triterpene Saponins from Actaea asiatica
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- 作者：Jingchun Gao ; Feng Huang ; Jinchao Zhang ; Guoyuan Zhu ; Mengsu Yang ; Peigen Xiao
- 刊名：Journal of Natural Products
- 出版年：2006
- 出版时间：October 2006
- 年：2006
- 卷：69
- 期：10
- 页码：1500 - 1502
- 全文大小：41K
- 年卷期：v.69,no.10(October 2006)
- ISSN：1520-6025
文摘
Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-
-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3--O-D-xyloside (5), and 25-anhydrocimigenol--O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structureswere established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicityagainst HepG2 and MCF-7 cancer cell lines.
-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3--O-D-xyloside (5), and 25-anhydrocimigenol--O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structureswere established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicityagainst HepG2 and MCF-7 cancer cell lines.