A Facile FeCl3/I2-Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones

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• 作者：Yuelu Zhu ; Cheng Li ; Jidong Zhang ; Mengyao She ; Wei Sun ; Kerou Wan ; Yaqi Wang ; Bin Yin ; Ping Liu ; Jianli Li
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3872-3875
• 全文大小：424K
• ISSN：1523-7052

文摘

A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl₃/I₂-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction conditions.