Highly Enantiomerically Enriched Planar Chiral Cyclopentadienyl(indenyl)ruthenium Complexes

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• 作者：Simon Wagschal ; Audrey Mercier ; E. Peter K眉ndig
• 刊名：Organometallics
• 出版年：2013
• 出版时间：December 9, 2013
• 年：2013
• 卷：32
• 期：23
• 页码：7133-7140
• 全文大小：418K
• 年卷期：v.32,no.23(December 9, 2013)
• ISSN：1520-6041

文摘

The functionalization of highly enantiomerically enriched planar chiral cyclopentadienyl(4-bromoindenyl)ruthenium complexes is detailed. Lithium/bromine exchange followed by an electrophilic quench using N,N-dimethylformamide (DMF), trimethylsilyl chloride, benzaldehyde, acetone, or 1,2-diiodoethane afforded the corresponding enantiomerically enriched planar chiral complexes. Suzuki鈥揗iyaura cross-coupling led to cyclopentadienyl(indenyl)ruthenium complexes bearing aryl and alkenyl groups in high yields. Similarly, in situ generation of the boronate intermediate using 9-MeO-9-BBN and a metalated species in the Suzuki鈥揗iyaura reaction gave heteroaryl, alkynyl, and alkyl cyclopentadienyl(indenyl)ruthenium complexes with retention of configuration and enantiomeric excess.