Increasing the Efficiency of the Transannular Diels鈥揂lder Strategy via Palladium(II)-Catalyzed Macrocyclizations

详细信息    查看全文

• 作者：Robert G. Iafe ; Jonathan L. Kuo ; Dustin G. Hochstatter ; Tomomi Saga ; Jonathan W. Turner ; Craig A. Merlic
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：February 1, 2013
• 年：2013
• 卷：15
• 期：3
• 页码：582-585
• 全文大小：351K
• 年卷期：v.15,no.3(February 1, 2013)
• ISSN：1523-7052

文摘

Palladium(II)-catalyzed macrocyclizations of bis(vinylboronate ester) compounds are demonstrated to provide a strategically efficient approach to transannular Diels鈥揂lder reaction substrates. In several systems reported, the macrocycle is preorganized such that cycloaddition at room temperature occurs concomitantly with cyclization. Numerous advantages over palladium(0)-catalyzed cross-coupling approaches are demonstrated.