Removal of Reaction Solvent by Extractive Workup: Survey of Water and Solvent Co-extraction in Various Systems

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• 作者：Laurent Delhaye ; Attilio Ceccato ; Pierre Jacobs ; Cindy Kö ; ttgen ; Alain Merschaert
• 刊名：Organic Process Research & Development
• 出版年：2007
• 出版时间：January 2007
• 年：2007
• 卷：11
• 期：1
• 页码：160 - 164
• 全文大小：371K
• 年卷期：v.11,no.1(January 2007)
• ISSN：1520-586X

文摘

In some chemical processes, extractive workup is used to removethe solvent of reaction in an aqueous layer and to isolate theproduct in the organic layer. Most of the time some reactionsolvent is co-extracted in the organic layer, along with somewater. This has a non-negligible impact on subsequent operations (washing, crystallization), and we have thus determinedthose levels for ten reaction solvents and five extraction solventsin order to help the process chemist in the development ofefficient isolation procedures.