Bioactive Compounds from the Fern Lepisorus contortus

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• 作者：Jian-Hong Yang ; Tamara P. Kondratyuk ; Katherine C. Jermihov ; Laura E. Marler ; Xi Qiu ; Yongsoo Choi ; Hongmei Cao ; Rui Yu ; Megan Sturdy ; Rong Huang ; Ying Liu ; Li-Qin Wang ; Andrew D. Mesecar ; Richard B. van Breemen ; John ; M. Pezzuto ; Harry H. S. Fong ; Ye-Gao Chen ; Hong-Jie Zhang
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：February 25, 2011
• 年：2011
• 卷：74
• 期：2
• 页码：129-136
• 全文大小：881K
• 年卷期：v.74,no.2(February 25, 2011)
• ISSN：1520-6025

文摘

Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1鈭?b>5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6鈭?b>9 and 11鈭?b>15, syringic acid, vanillic acid, phloretic acid, diplopterol, and 尾-sitosterol). This is the first report of phenylethanoid glycosides from the family Polypodiaceae. Compounds 1鈭?b>15 were evaluated for their cancer chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-伪)-induced NF-魏B activity, nitric oxide (NO) production, and aromatase, quinone reductase 2 (QR-2), and COX-1/-2 activities. Quercetin-3-O-尾-d-glucoside (15) demonstrated inhibition against QR2 with an IC₅₀ value of 3.84 渭M, which confirmed kaempferol/quercetin glycosides as the active compounds to inhibit QR2. The compound also demonstrated NF-魏B activity with an IC₅₀ value of 33.6 渭M. In addition, compounds 1, 2, 4, and 6 showed aromatase activity with IC₅₀ values of 30.7, 32.3, 26.8, and 35.3 渭M, respectively.