Dihydroagarofuranoid Sesquiterpenes, a Lignan Derivative, a Benzenoid, and Antitubercular Constituents from the Stem of Microtropis japonica

详细信息    查看全文

• 作者：Jih-Jung Chen ; Chang-Syun Yang ; Chien-Fang Peng ; Ih-Sheng Chen ; Chang-Ling Miaw
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：June 2008
• 年：2008
• 卷：71
• 期：6
• 页码：1016 - 1021
• 全文大小：164K
• 年卷期：v.71,no.6(June 2008)
• ISSN：1520-6025

文摘

Four new compounds, including two new dihydroagarofuranoid sesquiterpenes, 8-benzoyloxymutangin (1) and 15-acetoxyorbiculin G (2), a new lignan derivative, 9,9′-O-di-(Z)-feruloyl-(−)-secoisolariciresinol (3), and a new benzenoid, 5′-methoxyevofolin B (4), have been isolated from the stem of Microtropis japonica, together with 20 known compounds (5−24). 3-Ethoxy-4-hydroxybenzaldehyde (5) was identified from a natural source for the first time. The structures of these new compounds were determined through analyses of physical data. 15-Acetoxyorbiculin G (2), celahin C (6), and salasol A (7) exhibit antituberculosis activities (MICs ≤ 39.6 µM) against Mycobacterium tuberculosis H₃₇Rv in vitro.