Fumonisin B-Glucose Reaction Products Are Less Toxic When Fed to Swine
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- 作者：Guillermo Ferná ; ndez-Surumay ; Gary D. Osweiler ; Michael J. Yaeger ; George E. Rottinghaus ; Suzanne Hendrich ; Lucas K. Buckley ; and Patricia A. Murphy
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2005
- 出版时间：May 18, 2005
- 年：2005
- 卷：53
- 期：10
- 页码：4264 - 4271
- 全文大小：151K
- 年卷期：v.53,no.10(May 18, 2005)
- ISSN：1520-5118
文摘
The effects of fumonisin B-glucose reaction products in swine diets was examined. Pigs were feddiets containing 528 
mol of total fumonisin B/kg (FB), 528 mol of total FB-glucose adducts/kg(FB-G, 122 mol of unreacted FB/kg), or 0 mol of total FB/kg for 15 days to test the efficacy of theFB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls,which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase,
-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control pigs. Serumsphinganine/shingosine ratios in FB pigs were higher than in FB-G or control pigs. Microscopicexamination of tissues from FB pigs showed generalized liver necrosis and apoptosis with markedcellular pleomorphism and disorganized hepatic cords. The liver and kidneys in the FB-G groupappeared to be normal. Tissues of controls were free of lesions. Results suggest that dietary FB-Gproducts are less toxic to swine and may provide an detoxification approach in instances of widespreadFB grain contamination (p < 0.05).Keywords: Fumonisin B; fumonisin B-glucose; detoxification; swine
mol of total fumonisin B/kg (FB), 528 mol of total FB-glucose adducts/kg(FB-G, 122 mol of unreacted FB/kg), or 0 mol of total FB/kg for 15 days to test the efficacy of theFB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls,which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase,-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control pigs. Serumsphinganine/shingosine ratios in FB pigs were higher than in FB-G or control pigs. Microscopicexamination of tissues from FB pigs showed generalized liver necrosis and apoptosis with markedcellular pleomorphism and disorganized hepatic cords. The liver and kidneys in the FB-G groupappeared to be normal. Tissues of controls were free of lesions. Results suggest that dietary FB-Gproducts are less toxic to swine and may provide an detoxification approach in instances of widespreadFB grain contamination (p < 0.05).Keywords: Fumonisin B; fumonisin B-glucose; detoxification; swine