NMR Studies of Structure鈥揜eactivity Relationships in Carbonyl Reduction: A Collaborative Advanced Laboratory Experiment

详细信息    查看全文

• 作者：Simona Marincean ; Sheila R. Smith ; Michael Fritz ; Byung Joo Lee ; Zeinab Rizk
• 刊名：Journal of Chemical Education
• 出版年：2012
• 出版时间：November 13, 2012
• 年：2012
• 卷：89
• 期：12
• 页码：1591-1594
• 全文大小：181K
• 年卷期：v.89,no.12(November 13, 2012)
• ISSN：1938-1328

文摘

An upper-division laboratory project has been developed as a collaborative investigation of a reaction routinely taught in organic chemistry courses: the reduction of carbonyl compounds by borohydride reagents. Determination of several trends regarding structure鈥揳ctivity relationship was possible because each student contributed his or her results to an overall data set in a situation similar to a research environment. The students learned to use ¹H NMR techniques for in situ kinetic determinations and collaborated with classmates to develop a complete theory for structure鈥揳ctivity effects in the kinetics of this fundamental organic reaction.

Keywords:

d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Upper%5C-Division+Undergraduate&qsSearchArea=searchText">Upper-Division Undergraduate; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Laboratory+Instruction&qsSearchArea=searchText">Laboratory Instruction; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Organic+Chemistry&qsSearchArea=searchText">Organic Chemistry; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Physical+Chemistry&qsSearchArea=searchText">Physical Chemistry; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Collaborative%2FCooperative+Learning&qsSearchArea=searchText">Collaborative/Cooperative Learning; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Hands%5C-On+Learning%2FManipulatives&qsSearchArea=searchText">Hands-On Learning/Manipulatives; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Aldehydes%2FKetones&qsSearchArea=searchText">Aldehydes/Ketones; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Kinetics&qsSearchArea=searchText">Kinetics; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Mechanisms+of+Reactions&qsSearchArea=searchText">Mechanisms of Reactions; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=NMR+Spectroscopy&qsSearchArea=searchText">NMR Spectroscopy