Recycling and Imaging of Nuclear Singlet Hyperpolarization

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• 作者：Giuseppe Pileio ; Sean Bowen ; Christoffer Laustsen ; Michael C. D. Tayler ; Joseph T. Hill-Cousins ; Lynda J. Brown ; Richard C. D. Brown ; Jan H. Ardenkjaer-Larsen ; Malcolm H. Levitt
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：April 3, 2013
• 年：2013
• 卷：135
• 期：13
• 页码：5084-5088
• 全文大小：276K
• 年卷期：v.135,no.13(April 3, 2013)
• ISSN：1520-5126

文摘

The strong enhancement of NMR signals achieved by hyperpolarization decays, at best, with a time constant of a few minutes. Here, we show that a combination of long-lived singlet states, molecular design, magnetic field cycling, and specific radiofrequency pulse sequences allows repeated observation of the same batch of polarized nuclei over a period of 30 min and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. MRI experiments may be run on a portion of the available spin polarization, while the remaining is preserved and made available for a later use. An analogy is drawn with a 鈥渟pin bank鈥?or 鈥渞esealable container鈥?in which highly polarized spin order may be deposited and retrieved.