文摘
The dynamic kinetic resolution of 伪-keto esters via asymmetric transfer hydrogenation has been developed as a technique for the highly stereoselective construction of structurally diverse 尾-substituted-伪-hydroxy carboxylic acid derivatives. Through the development of a privileged m-terphenylsulfonamide for (arene)RuCl(monosulfonamide) complexes with a high affinity for selective 伪-keto ester reduction, excellent levels of chemo-, diastereo-, and enantiocontrol can be realized in the reduction of 尾-aryl- and 尾-chloro-伪-keto esters.