Chemoselective Dimerization of Phosphates
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- 作者：Alexandre Hofer ; Elia Marques ; Nicole Kieliger ; Sarah-Kirsten N. Gatter ; Sara Jordi ; Elena Ferrari ; Manuel Hofmann ; Teresa B. Fitzpatrick ; Michael O. Hottiger ; Henning J. Jessen
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：July 1, 2016
- 年：2016
- 卷：18
- 期：13
- 页码：3222-3225
- 全文大小：326K
- 年卷期：0
- ISSN：1523-7052
文摘
A methodology for the synthesis of oligophosphate conjugates using phosphordiamidites is described. This strategy facilitates the straightforward preparation of C2-symmetric dinucleoside tri-, penta-, and heptaphosphates. Moreover, unsymmetric compounds such as thiamine adenosine triphosphate and thiamine cytidine triphosphate can be prepared. The material is used to study the inhibitory activity of thiaminylated nucleotides against adenosine diphosphate ribosyltransferases.