Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography
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- 作者：Kimberly R. Kam ; Laura A. Walsh ; Suzanne M. Bock ; Michael Koval ; Kathleen E. Fischer ; Russell F. Ross ; Tejal A. Desai
- 刊名：Nano Letters
- 出版年：2013
- 出版时间：January 9, 2013
- 年：2013
- 卷：13
- 期：1
- 页码：164-171
- 全文大小：450K
- 年卷期：v.13,no.1(January 9, 2013)
- ISSN：1530-6992
文摘
Herein, we demonstrate that nanotopographical cues can be utilized to enable biologics >66 kDa to be transported across epithelial monolayers. When placed in contact with epithelial monolayers, nanostructured thin films loosen the epithelial barrier and allow for significantly increased transport of FITC-albumin, FITC-IgG, and a model therapeutic, etanercept. Our work highlights the potential to use drug delivery systems which incorporate nanotopography to increase the transport of biologics across epithelial tissue.