Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vit
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- 作者：Mark O鈥機onnor ; Andrew Kellett ; Malachy McCann ; Georgina Rosair ; Mary McNamara ; Orla Howe ; Bernadette S. Creaven ; Siobh谩n McClean ; Agnieszka Foltyn-Arfa Kia ; Denis O鈥橲hea ; Michael Devereux
- 刊名：Journal of Medicinal Chemistry
- 出版年：2012
- 出版时间：March 8, 2012
- 年：2012
- 卷：55
- 期：5
- 页码：1957-1968
- 全文大小：450K
- 年卷期：v.55,no.5(March 8, 2012)
- ISSN：1520-4804
文摘
The complexes [Cu(salH)2(H2O)] (1), [Cu(dipsH)2(H2O)] (2), {Cu(3-MeOsal)(H2O)0.75}n (3), [Cu(dipsH)2(BZDH)2] (4), [Cu(dipsH)2(2-MeOHBZDH)2]路EtOH (5), [Cu(sal)(phen)] (6), [Cu(dips)(phen)]路H2O (7), and [Cu(3-MeOsal)(phen)]路H2O (8) (salH2 = salicylic acid; dipsH2 = 3,5-diisopropylsalicylic acid; 3-MeOsalH2 = 3-methoxysalicylic acid; BZDH = benzimidazole; 2-MeOHBZDH = 2 methanolbenzimidazole and phen =1,10-phenanthroline) were prepared and characterized. Structures of 4, 5, and 8 were determined by X-ray crystallography. Compounds 1鈥?b>8 are potent superoxide dismutase mimetics, and they are inactive as inhibitors of COX-2 activity. Compounds 1, 4, and 5 exhibit moderate inhibition of COX-1. Complexes 6鈥?b>8 display rapid micromolar cytotoxicity against cisplatin sensitive (breast (MCF-7), prostate (DU145), and colon (HT29)) and cisplatin resistant (ovarian (SK-OV-3)) cell lines compared to 1鈥?b>5, and they exhibit potent in vitro DNA binding and cleavage capabilities.