Singlet Oxygen Production by Peptide-Coated Quantum Dot-Photosensitizer Conjugates

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• 作者：James M. Tsay ; Michael Trzoss ; Lixin Shi ; Xiangxu Kong ; Matthias Selke ; Michael E. Jung ; Shimon Weiss
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：May 30, 2007
• 年：2007
• 卷：129
• 期：21
• 页码：6865 - 6871
• 全文大小：255K
• 年卷期：v.129,no.21(May 30, 2007)
• ISSN：1520-5126

文摘

Peptide-coated quantum dot-photosensitizer conjugates were developed using novel covalentconjugation strategies on peptides which overcoat quantum dots (QDs). Rose bengal and chlorin e6,photosensitizers (PSs) that generate singlet oxygen in high yield, were covalently attached to phytochelatin-related peptides. The photosensitizer-peptide conjugates were subsequently used to overcoat green- andred-emitting CdSe/CdS/ZnS nanocrystals. Generation of singlet oxygen could be achieved via indirectexcitation through Förster (fluorescence) resonance energy transfer (FRET) from the nanocrystals to PSs,or by direct excitation of the PSs. In the latter case, by using two color excitations, the conjugate could besimultaneously used for fluorescence imaging and singlet oxygen generation. Singlet oxygen quantumyields as high as 0.31 were achieved using 532-nm excitation wavelengths.