Improved Carbohydrate Recognition in Water with an Electrostatically Enhanced 尾-Peptide Bundle

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• 作者：Michael S. Melicher ; Allison S. Walker ; John Shen ; Scott J. Miller ; Alanna Schepartz
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：October 2, 2015
• 年：2015
• 卷：17
• 期：19
• 页码：4718-4721
• 全文大小：389K
• ISSN：1523-7052

文摘

The selective recruitment of oligosaccharides, or even simple sugars, in water solvent is an unsolved molecular recognition problem. Structure-guided, electrostatic redesign led to a significant increase in the affinity of a 尾-peptide 鈥渂orono-bundle鈥?for simple sugars in neutral aqueous solution. The affinity for fructose (663 M^鈥?) in water should allow its recruitment to the bundle surface for selective catalysis, and future work will focus in this direction.