Kinetic Diversity of Striatal Dopamine: Evidence from a Novel Protocol for Voltammetry

详细信息    查看全文

• 作者：Seth H. Walters ; Elaine M. Robbins ; Adrian C. Michael
• 刊名：ACS Chemical Neuroscience
• 出版年：2016
• 出版时间：May 18, 2016
• 年：2016
• 卷：7
• 期：5
• 页码：662-667
• 全文大小：420K
• 年卷期：0
• ISSN：1948-7193

文摘

In vivo voltammetry reveals substantial diversity of dopamine kinetics in the rat striatum. To substantiate this kinetic diversity, we evaluate the temporal distortion of dopamine measurements arising from the diffusion-limited adsorption of dopamine to voltammetric microelectrodes. We validate two mathematical procedures for correcting adsorptive distortion, both of which substantiate that dopamine’s apparent kinetic diversity is not an adsorption artifact.