Ovarian Cancer Activity of Cyclic Amine and Thiaether Metal Complexes
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文摘
A thiaether metal complex 1-aza-4,7-dithiacyclononane-RhCl3, 2, and cyclic amine metal complexes tacn-CuBr2, 3, and Me3tacn-RuCl3, 4, have been evaluated for anticancer activity against the ovarian cancercell line NuTu-19 and for cell toxicity against the noncancerous ovarian tissue cell line OVepi. Specifically,metal complex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cellinvasion assay. The in vitro results reported warrant further evaluation of metal complex 2 in living systems.

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