Crystal Structure of BRL 42715, C6-(N1-Methyl-1,2,3-triazolylmethylene)penem, in Complex with Enterobacter cloacae 908R 
fchars/beta2.
fchars/beta2.
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- 作者：Catherine Michaux ; Paulette Charlier ; Jean-Marie Frè ; re ; and Johan Wouters
- 刊名：Journal of the American Chemical Society
- 出版年：2005
- 出版时间：March 16, 2005
- 年：2005
- 卷：127
- 期：10
- 页码：3262 - 3263
- 全文大小：95K
- 年卷期：v.127,no.10(March 16, 2005)
- ISSN：1520-5126
文摘
BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, is an active-site-directed inactivator of bacterial 
fchars/beta2.gif" BORDER=0 ALIGN="middle">-lactamases. The crystal structure of Enterobacter cloacae 908R class C fchars/beta2.gif" BORDER=0 ALIGN="middle">-lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C fchars/beta2.gif" BORDER=0 ALIGN="middle">-lactamase.
fchars/beta2.gif" BORDER=0 ALIGN="middle">-lactamases. The crystal structure of Enterobacter cloacae 908R class C fchars/beta2.gif" BORDER=0 ALIGN="middle">-lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C fchars/beta2.gif" BORDER=0 ALIGN="middle">-lactamase.