Nucleoside–Lipid-Based Nanoparticles for Cisplatin Delivery

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• 作者：Salim Khiati ; Delphine Luvino ; Khalid Oumzil ; Bruno Chauffert ; Michel Camplo ; Philippe Barthélémy
• 刊名：ACS Nano
• 出版年：2011
• 出版时间：November 22, 2011
• 年：2011
• 卷：5
• 期：11
• 页码：8649-8655
• 全文大小：878K
• 年卷期：0
• ISSN：1936-086X

文摘

The use of delivery vehicles to selectively transport anticancer agents to tumors is very attractive to address both toxicity and efficacy issues. We report a novel approach based on hybrid nucleoside–lipids allowing the efficient encapsulation and delivery of cisplatin. We demonstrate that the nucleoside polar heads guide the self-assembly of the aggregates into highly loaded and stable nanoparticles. The nanoparticles, which are efficient vehicles for the delivery of cisplatin into different sensitive and resistant cancer cell lines, can overcome the disadvantages and limitations of drug delivery systems previously reported.