Neopyrrolomycins with Broad Spectrum Antibacterial Activity
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- 作者：D. Craig Hopp ; Joshua Rhea ; Daniel Jacobsen ; Khadidja Romari ; Chris Smith ; John Rabenstein ; Macarena Irigoyen ; Midori Clarke ; Linda Francis ; Michele Luche ; Grant J. Carr ; Ulla Mocek*
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：February 27, 2009
- 年：2009
- 卷：72
- 期：2
- 页码：276-279
- 全文大小：97K
- 年卷期：v.72,no.2(February 27, 2009)
- ISSN：1520-6025
文摘
Three new antibiotics, neopyrrolomycins B (1), C (2), and D (3), with potent activity against Gram-positive pathogens were discovered. They exhibited MIC values < 1 μg/mL versus a number of resistant strains. The compounds were obtained from the ethyl acetate extracts of a Streptomyces sp. after purification by column chromatography and RP-HPLC. Their structures were elucidated using X-ray crystallography (1) and NMR spectroscopy (2 and 3).