Novel Axially Chiral Phosphine Ligand with a Fluoro Alcohol Moiety for Rh-Catalyzed Asymmetric Arylation of Aromatic Aldehydes

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• 作者：Satoshi Morikawa ; Kyosuke Michigami ; Hideki Amii
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：June 4, 2010
• 年：2010
• 卷：12
• 期：11
• 页码：2520-2523
• 全文大小：199K
• 年卷期：v.12,no.11(June 4, 2010)
• ISSN：1523-7052

文摘

A new chiral phosphine ligand (R)-1 possessing a fluoroalcohol moiety was prepared. The (R)-1-coordinated Rh(I) complex showed an excellent catalytic activity for asymmetric 1,2-addition of arylboronic acids to aldehydes to afford highly enantioenriched diarylmethanols. The fluoroalcohol moiety in ligand (R)-1 plays a pivotal role for the high enantioselectivity of the present Rh(I)-catalyzed transformation.