Synthesis and Characterization of Novel Indole Derivatives Reveal Improved Therapeutic Agents for Treatment of Ischemia/Reperfusion (I/R) Injury

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• 作者：Wei Bi ; Yue Bi ; Ping Xue ; Yanrong Zhang ; Xiang Gao ; Zhibo Wang ; Meng Li ; Michle Baudy-Floc&#8217 ; h ; Nathaniel Ngerebara ; K. Michael Gibson ; Lanrong Bi
• 刊名：Journal of Medicinal Chemistry
• 出版年：2010
• 出版时间：September 23, 2010
• 年：2010
• 卷：53
• 期：18
• 页码：6763-6767
• 全文大小：861K
• 年卷期：v.53,no.18(September 23, 2010)
• ISSN：1520-4804

文摘

To develop more potent therapeutic agents with therapeutic efficacy for ischemia/reperfusion (I/R) injury, we linked an antiinflammatory moiety (1,3-dioxane derivative) to the key pharmacophoric moiety of melatonin. We hypothesized that the resulting new indole derivatives might induce a synergistic protection against oxidative damage associated with I/R injury. Our results indicate that one of these indole derivatives (7) manifests potent antiinflammatory antioxidant effects and exerts a protective effect against skeletal muscle injury and associated lung injury following limb I/R in rats.