Anticancer Peptide SVS-1: Efficacy Precedes Membrane Neutralization

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• 作者：Diana Gaspar ; Ana Salom茅 Veiga ; Chomdao Sinthuvanich ; Joel P. Schneider ; Miguel A. R. B. Castanho
• 刊名：Biochemistry
• 出版年：2012
• 出版时间：August 14, 2012
• 年：2012
• 卷：51
• 期：32
• 页码：6263-6265
• 全文大小：171K
• 年卷期：v.51,no.32(August 14, 2012)
• ISSN：1520-4995

文摘

Anticancer peptides are polycationic amphiphiles capable of preferentially killing a wide spectrum of cancer cells relative to noncancerous cells. Their primary mode of action is an interaction with the cell membrane and subsequent activation of lytic effects; however, the exact mechanism responsible for this mode of action remains controversial. Using zeta potential analyses we demonstrate the interaction of a small anticancer peptide with membrane model systems and cancer cells. Electrostatic interactions have a pivotal role in the cell killing process, and in contrast to the antimicrobial peptides action cell death occurs without achieving full neutralization of the membrane charge.