One-Pot, Two-Step Synthesis of Substituted Anthraquinones from Chromium(0) Alkynyl Carbenes and Isobenzofurans

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• 作者：José ; Barluenga ; Silvia Mart&iacute ; nez ; Angel L. Suá ; rez-Sobrino ; Miguel Tomá ; s
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：February 21, 2008
• 年：2008
• 卷：10
• 期：4
• 页码：677 - 679
• 全文大小：89K
• 年卷期：v.10,no.4(February 21, 2008)
• ISSN：1523-7052

文摘

The reaction of alkynyl Fischer carbenes and isobenzofurans gives rise to the corresponding [4 + 2] cycloadducts. The newly formed carbeneadducts are suitable for benzannulation processes in the presence of tert-butylisocyanide or carbon monoxide to yield a variety of new highlysubstituted polycyclic structures having the anthraquinone framework. The whole two-step process is conducted in a one-pot fashion fromeasily available 1,4-dihydro-1,4-epoxynaphthalenes.