Isolable
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-amino
N-
tert-butanesulfinimines were prepared through the condensation of Reetz's
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-amino aldehydes (prepared from
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-amino acids) with Ellman's (
R)-
N-
tert-butanesufinamide without any racemization, and these were trifluoromethylated with TMSCF
3 and TMAF (tetramethylammonium fluoride) to the corresponding vicinal ethylenediamines derivatives. Imines derived from
L-amino acids gave exclusively one diastereomer with a very high yield.