Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog
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- 作者：Thordur Oskarsson ; Pavel Nagorny ; Isaac J. Krauss ; Lucy Perez ; Mihirbaran Mandal ; Guangli Yang ; Ouathek Ouerfelli ; Danhua Xiao ; Malcolm A. S. Moore ; Joan Massagu ; Samuel J. Danishefsky
- 刊名：Journal of the American Chemical Society
- 出版年：2010
- 出版时间：March 10, 2010
- 年：2010
- 卷：132
- 期：9
- 页码：3224-3228
- 全文大小：222K
- 年卷期：v.132,no.9(March 10, 2010)
- ISSN：1520-5126
文摘
A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.