Palladium(II)-Mediated Addition of Benzenediamines to Isocyanides: Generation of Three Types of Diaminocarbene Ligands Depending on the Isomeric Structure of the Nucleophile

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• 作者：Mikhail A. Kinzhalov ; Svetlana A. Timofeeva ; Konstantin V. Luzyanin ; Vadim P. Boyarskiy ; Anton A. Yakimanskiy ; Matti Haukka ; Vadim Yu. Kukushkin
• 刊名：Organometallics
• 出版年：2016
• 出版时间：January 25, 2016
• 年：2016
• 卷：35
• 期：2
• 页码：218-228
• 全文大小：618K
• ISSN：1520-6041

文摘

Coupling of the palladium-bis(isocyanide) complexes cis-[PdCl₂(CNR)₂] (R = 2,6-Me₂C₆H₃ 1, 2-Cl-6-MeC₆H₃ 2) with benzene-1,3-diamine (BDA1) leads to the diaminocarbene species cis-[PdCl₂(CNR){C(NHR)═NH(1,3-C₆H₄NH₂)}] (5 and 6, respectively). In this reaction, BDA1 behaves as a monofunctional nucleophile that adds to one of the RNC ligands by one amino group. By contrast, the reaction of 1 and 2 with benzene-1,4-diamine (BDA2) involves both amino functionalities of the diamine and leads to the binuclear species [cis-PdCl₂(CNR){μ-C(NHR)═NH(1,4-C₆H₄)NH═C(NHR)}-(cis)-PdCl₂(CNR)] (6 and 7) featuring two 1,4-bifunctional diaminocarbene ligands. The reaction of cis-[PdCl₂(CNR)₂] (R = cyclohexyl 3) with either BDA1 or BDA2 does not afford any isolable carbene derivatives. The most versatile chemistry was observed when 1–3 were treated with benzene-1,2-diamine (BDA3) and the relevant substituted 1,2-diamines, viz., 4,5-dimethylbenzene-1,2-diamine (BDA4) and 4,5-dichlorobenzene-1,2-diamine (BDA5). The addition of these diamines brings about the formation of the monocarbene cationic complexes cis-[PdCl(CNR){C(NHR)═NHC₆H₂X₂NH₂}]Cl (X = H, Me, Cl) (8–16), the Chugaev-type C,C-bound bis-carbenes cis-[PdCl₂{C(NHR)═NHC₆H₂X₂NH═C(NHR)}] (17, 18), and the bis(C,N-chelated)carbene complexes cis-[Pd{C(NHR)═NHC₆H₂X₂NH₂}₂]Cl₂ (19–24). All prepared complexes (with the exception of 17 and 18) were isolated as colorless or pale yellow solids and characterized by elemental analyses (C, H, N), HRESI^±-MS, IR, ¹H and ¹³C{¹H} NMR spectroscopies, and 4, 7, 13, 16, and 24 by X-ray diffraction. Complexes 17 and 18 were characterized by HRESI^±-MS and IR spectroscopy, and their structures were established by X-ray crystallography.