Synthesis of Dihydrobenzofurans with Quaternary Carbon Center under Mild and Neutral Conditions

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• 作者：Norihiko Takeda ; Masafumi Ueda ; Syunsuke Kagehira ; Hiroyuki Komei ; Norimitsu Tohnai ; Mikiji Miyata ; Takeaki Naito ; Okiko Miyata
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：September 6, 2013
• 年：2013
• 卷：15
• 期：17
• 页码：4382-4385
• 全文大小：261K
• 年卷期：v.15,no.17(September 6, 2013)
• ISSN：1523-7052

文摘

A new method has been developed for the construction of dihydrobenzofurans from O-aryloxime ethers bearing an 伪-cyano group using a sequential regioselective isomerization/[3,3]-sigmatropic rearrangement/cyclization reaction in MeOH without any catalysts under neutral conditions at ambient temperature. The current transformation provides environmentally benign and atom-economical access to a variety of dihydrobenzofurans containing a quaternary carbon from readily available cyclic and acyclic oxime ethers.