3,3'-Dipyridyl BINOL Ligands. Synthesis and Application in Enantioselective Addition of Et2Zn to Aldehydes

详细信息    查看全文

• 作者：Robert R. Milburn ; S. M. Shakil Hussain ; Olaf Prien ; Zaheer Ahmed ; Victor Snieckus
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：October 25, 2007
• 年：2007
• 卷：9
• 期：22
• 页码：4403 - 4406
• 全文大小：209K
• 年卷期：v.9,no.22(October 25, 2007)
• ISSN：1523-7052

文摘

3,3'-Di(2-pyridyl) BINOLs (4), prepared in three steps from commercial substances by a combined directed ortho metalation-Negishi cross-coupling protocol, constitute new members of the BINOL ligand family. They are among the most selective, general ligands, providing equalor greater stereoselectivities in the Et₂Zn addition to benzaldehydes and cinnamaldehydes (Table 3) than any single BINOL ligand reported todate.